Aromatase Inhibition: Translation into a Successful Therapeutic Approach

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چکیده

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Aromatase inhibition: translation into a successful therapeutic approach.

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Aromatase is the key enzyme in the synthesis of estrogens and mediates the conversion of androstenedione and testosterone to estrone and estradiol. Because of the importance of estrogen in stimulating breast cancers, the inhibition of estrogen synthesis is a logical approach to treatment. Aromatase is an excellent target for inhibition, because it is the last step in steroid biosynthesis, and, ...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2005

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-04-2187